Sunday, May 24, 2026

Matthew Perry Autopsy: M. E. Says “Acute Effects of Ketamine” Cause of Accidental Death, Along with Heart Disease, Drowning, and Other Drug

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Here’s the medical examiner’s statement on Matthew Perry:

“The County of Los Angeles Department of Medical Examiner (DME) determined the cause of death for 54-year-old actor Matthew Langford Perry as the acute effects of ketamine. Contributing factors in Mr. Perry’s death include drowning, coronary artery disease and the effects of buprenorphine (used to treat opioid use disorder). The manner of death is accident.”

Perry, a star of “Friends,” died October 28th in Los Angeles. His assistant found him unresponsive in his hot tub.

Perry had suffered for years from substance abuse, alcoholism, and depression. He published a memoir detailing his issues, and was working hard to be sober and help others. It’s a tragic end for such a talented, smart guy.

The report says that Perry had been on Ketamine drip for depression, but that the amount they found suggested he might have been taking it on his own.

“At the high levels of ketamine found in his postmortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression,” the autopsy report said. The amount of Ketmaine in Perry’s system was a level of 3,271 nanograms per milliliter. During monitored general anesthesia, levels range between 1,000 and 6,000 nanograms per milliliter, officials said.

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Roger Friedman
Roger Friedmanhttps://www.showbiz411.com
Roger Friedman is the founder and editor-in-chief of Showbiz411. He wrote the FOX411 column on FoxNews.com from 1999 to 2009 and previously edited Fame magazine and wrote the "Intelligencer" column at New York magazine. His bylines have appeared in The New York Times, The Washington Post, the New York Daily News, the New York Post, Vogue, Details, and the Miami Herald. He is a voting member of the Critics Choice Awards (Film and Television branches), and his movie reviews are tracked by Rotten Tomatoes. is articles have appeared in dozens of publications over the years including New York Magazine, where he wrote the Intelligencer column in the mid 90s and covered the OJ Simpson trial, and Fox News (when it wasn't so crazy) where he covered Michael Jackson. With D.A. Pennebaker and Chris Hegedus, he co-produced the 2002 documentary "Only the Strong Survive," which screened at Directors' Fortnight at the Cannes Film Festival.

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